Revised SPCs: Efient (prasugrel) 5 mg 10 mg film-coated tablets

electronic Medicines compendium

SPCs have been updated to advise a delayed and decreased exposure to oral P2Y12 inhibitors, including prasugrel and active metabolite, has been observed in patients with ACS treated with morphine. This interaction may be related to reduced GI motility and apply to other opioids.

Atrial fibrillation and human immunodeficiency virus type‐1 infection: a systematic review: Implications for anticoagulant and antiarrhythmic therapy

British Journal of Clinical Pharmacology

Authors of this narrative review reflect that HIV infection increases the risk of stroke. Choosing antiretrovirals with the lowest drug–drug interaction and with lower impact on the cardiovascular system, and the use of DOACs may help reduce the risk of stroke in this group.

The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:

http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services